10.00 请问生存分析中风险评估公式该怎么理解

项目进度

  • 发布需求

    2018-04-07

  • 威客交稿

    2018-04-27

  • 雇主选稿

    2018-05-02

  • 公示期

    2018-05-02

  • 5

    评价

需求描述

Table 1 Four lncRNAs were significantly associated with the CC survival in the test data set:

Gnene symbole   Coefficient              Hazard ratio     P value cox     P value permutation
AATBC                  0.7521141               0.471369            6.69E-04                    0.0004
NCK1-AS1           1.0531199                2.8665807          3.25E-05                    0.00234
LINC00937           -1.0104329              0.3640613         3.06E-05                         0
LINC00173           -0.4792615              0.6192405         1.03E-02                      0.0064

A set of fourlncRNA signatures were significantly correlated with patients’ survival (P < 0.0001; Table 1). Based on the ex pression of these four lncRNAs for DFS prediction, established a risk-score formula as follows: Risk score = (0.7521141×ex pression level of AATBC) + (1.0531199×ex pression level of NCK1-AS1) + (1.0104329×ex pression level of LINC00937) + (-0.4792615×ex pression level of LINC00173) Then, the four-lncRNA ex pression signature risk score for each patient in the training set were calculated. Patients were
divided into low-risk (n = 50) and high-risk (n = 50) groups according to the median risk score as cut-off in the training set. As shown in Fig. 1a patients in the high-risk group had significantly shorter survival times than those in the low-risk group (P < 0.0001).

请问表一中coefficient的-表示下调吗?

这几个指标 Coefficient  Hazard ratio  P value cox  P value permutation该怎么理解呢?

这段话提到风险评估公式,这个是咋建立的呀?

建立完怎么就把病人分成了低危和高危组呢?


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